Monday, November 21, 2011

Primary Immunodeficiency Diseases: A Molecular & Cellular Approach Review

Primary Immunodeficiency Diseases: A Molecular and Cellular Approach
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The second edition is now much improved over the first, which I also own and have read sections of numerous times. The authors do a great job of clearly providing information about a subject matter that is complex and rapidly changing. I refer to this book at least 1-2 times per week, if not more often. A must have for anybody practicing clinical immunology, as well as a great reference for physicians training in allergy & immunology.

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The second edition of Primary Immunodeficiency Diseases presents discussions of gene identification, mutation detection, and clinical and research applications for over 100 genetic immune disorders--disorders featuring an increased susceptibility to infections and, in certain conditions, an icreased rate of malignancies and autoimmune disorders. Since the publication of the first edition, a flurry of new disease entities has been defined and new treatment regimens have been introduced, the most spectacular being successful treatment by gene therapy for two genotypes of combined immunodeficiency. The first edition marked a historic turning point in the field of immunodeficiencies, demonstrating that many of the disorders of the immune systam could be understood at a molecular level. This new edition can proudly document the tremendous pace of progress in dissecting the complex immunologic networks responsible for protecting individuals from these disorders.

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