Sunday, March 4, 2012

Pharmacology for Chemists Review

Pharmacology for Chemists
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This book is a one stop shop for Chemists wanting to be familiar with the essentials of Pharmacology. Cannon also adopts the same perspective, always giving stress on the chemical basis of the action of drugs, as well as neurotransmitters, hormones and intracellular signalling molecules. The first part of the book deals with general principles, which Cannon beautifully explains in a nutshell. Topics include the blood-brain barrier, drug receptors, pharmacological assays, metabolic inactivation and modifications of drugs by organs, basic pharmacokinetics, and properties of membranes and cells. The latter part is focused on particular systems. It is especially in discussing the Central Nervous System that the book really shines. Cannon talks in detail about the neurochemistry and physiological action of several important neurotransmitters and their agonists & antagonists. He also discusses the most important diseases arising from malfunctioning of the CNS. The chemistry of addiction also receives due exaplanation. Later chapters include discussions of cardiovascular drugs and drugs which are used to treat Asthma and Allergies.
Pharmacology is a vast science, and it not possible for a utilitarian chemist to work through the grand tomes on the subject to get what he wants. Cannon's book largely remedies this situation, and provides him with the essentials, without overloading him with information. This slim volume is a must on the shelves of Medicinal Chemists, Biochemists and any professional working in, or interested in Drug Design.

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"Pharmacology for Chemists, Second Edition" is aimed at industrial and academic organic chemists holding advanced degrees who are entering the field of medicinal chemistry, and who have had little or no education in or exposure to the biological sciences, especially physiology and pharmacology. The first portion of this book concentrates on biological/pharmacological principles and concepts, and the second portion demonstrates how these concepts and principles are applicable to the medicinal chemists efforts, by describing some selected categories of drugs as examples. The book is not intended to be a textbook of pharmacology, but rather is intended to serve as a tool to prepare the reader for further study and more in depth reading.

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