Average Reviews:
(More customer reviews)Process development is generally not taught in schools. However it is the everyday practice of many industrial chemists. The book is really helpful in bridging these two quite different aspects of organic synthesis. It describes the issues, problems, and solutions in scale-up. It also covers environmental and regulatory issues and more importantly, commonly and preferrably used solvents and reagents in large scale operations. Real examples from pharmaceuticals are used to demonstrate all these issues and the way to synthesize fine chemicals in multi-kilogram quantities instead of laboratory milligram scale.
An excellent small book, easy and fun to read. Recommended to both the experienced and beginners.
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Process development bridges the gap between the laboratory synthesis of an organic compound and its industrial manufacture on a large scale. This concise and readable text uses real examples and case histories from ICI/Zeneca Pharmaceuticals to show the problems which may be encountered in scaling up chemical synthesis, and the ways these problems may be overcome. It shows how it is possible to synthesize multi-kilogram quantities of a new organic compound which has been made in the laboratory only in the milligram scale. A wide range of aliphatic, aromatic, and heterocyclic compounds is covered. This book will be invaluable both to the research chemist involved in the development phase of novel compounds, and the advanced undergraduate interested in the fine chemicals industry.
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